REVIEW: From Cellular Architecture to Regulation of Mitochondrial Function: Role of Vimentin in Ensuring Cellular Mitostasis

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Roaa Deeb^1,2, Anton S. Shakhov^1,3, Aleksandra S. Churkina^1,3, Irina B. Alieva^1,3, and Alexander A. Minin^1,a*

¹Institute of Protein Research, Russian Academy of Sciences, 119334 Moscow, Russia

²Moscow Institute of Physics and Technology (MIPT), 141701 Dolgoprudny, Moscow Region, Russia

³Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russia

^* To whom correspondence should be addressed.

Received: August 31, 2025; Revised: October 17, 2025; Accepted: November 11, 2025

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Mitochondria play a central role in cell physiology, and in addition to performing their primary function as an energy source, they are involved in processes such as regulating intracellular calcium levels, generating reactive oxygen species, synthesizing many critical compounds, regulating apoptosis, and more. In this regard, maintaining them in a normal state is of great importance, ensuring their transport, intracellular distribution, timely biogenesis, and removal of damaged mitochondria from the cells. All of this is defined as cellular mitostasis, maintenance of which involves many cellular structures and, primarily, the cytoskeleton. This review summarizes the data on the role of one component of cytoskeleton, vimentin intermediate filaments, in these processes.

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KEY WORDS: cytoskeleton, microtubules, actin filaments, intermediate filaments, vimentin filaments, mitochondria

DOI: 10.1134/S0006297925602813

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