REVIEW: Contribution of Visceral Systems to the Development of Substance Use Disorders: Translational Aspects of Interaction between Central and Peripheral Mechanisms

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Danil I. Peregud^1,2,a*, Natalia V. Gulyaeva^2,3

¹Serbsky National Medical Research Center for Psychiatry and Drug Addiction, Ministry of Health of the Russian Federation, 119034 Moscow, Russia

²Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, 117485 Moscow, Russia

³Research and Clinical Center for Neuropsychiatry of Moscow Healthcare Department, 115419 Moscow, Russia

^* To whom correspondence should be addressed.

Received: May 27, 2024; Revised: July 8, 2024; Accepted: July 11, 2024

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Substance use disorders are associated with structural and functional changes in the neuroendocrine, neuromediator, and neuromodulator systems in brain areas involved in the reward and stress response circuits. Chronic intoxication provokes emergence of somatic diseases and aggravates existing pathologies. Substance use disorders and somatic diseases often exacerbate the clinical courses of each other. Elucidation of biochemical pathways common for comorbidities may serve as a basis for the development of new effective pharmacotherapy agents, as well as drug repurposing. Here, we discussed molecular mechanisms underlying integration of visceral systems into the central mechanisms of drug dependence.

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KEY WORDS: psychoactive substances, dependence, brain, visceral systems, neuroendocrine mechanisms, neuromediators, neuromodulators, internal diseases

DOI: 10.1134/S0006297924110026

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