REVIEW: Activity of DNA Repair Systems in the Cells of Long-Lived Rodents and Bats

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Aleksei A. Popov¹, Irina O. Petruseva¹, Olga I. Lavrik^1,2,a*

¹Institute of Chemical Biology and Fundamental Medicine, Siberian Branch Russian Academy of Sciences, 630090 Novosibirsk, Russia

²Novosibirsk National Research State University, 630090 Novosibirsk, Russia

^* To whom correspondence should be addressed.

Received: January 24, 2024; Revised: March 15, 2024; Accepted: April 3, 2024

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Damages of various origin accumulated in the genomic DNA can lead to the breach of genome stability, and are considered to be one of the main factors involved in cellular senescence. DNA repair systems in mammalian cells ensure effective damage removal and repair of the genome structure, therefore, activity of these systems is expected to be correlated with high maximum lifespan observed in the long-lived mammals. This review discusses current results of the studies focused on determination of the DNA repair system activity and investigation of the properties of its key regulatory proteins in the cells of long-lived rodents and bats. Based on the works discussed in the review, it could be concluded that the long-lived rodents and bats in general demonstrate high efficiency in functioning and regulation of DNA repair systems. Nevertheless, a number of questions around the study of DNA repair in the cells of long-lived rodents and bats remain poorly understood, answers to which could open up new avenues for further research.

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KEY WORDS: DNA repair, cellular senescence, longevity, poly(ADP-ribose)polymerase 1, sirtuin 6

DOI: 10.1134/S0006297924060038

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