REVIEW: Mitocentricity

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Dmitry B. Zorov^1,2,a*, Polina A. Abramicheva¹, Nadezda V. Andrianova¹, Valentina A. Babenko^1,2, Ljubava D. Zorova^1,2, Savva D. Zorov^1,3, Irina B. Pevzner^1,2, Vasily A. Popkov^1,2, Dmitry S. Semenovich¹, Elmira I. Yakupova¹, Denis N. Silachev^1,2, Egor Y. Plotnikov^1,2, and Gennady T. Sukhikh²

¹Belozersky Research Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia

²Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology, 117997 Moscow, Russia

³Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, 119991 Moscow, Russia

Received December 29, 2023; Revised January 19, 2024; Accepted January 21, 2024

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Worldwide, interest in mitochondria is constantly growing, as evidenced by scientific statistics, and studies of the functioning of these organelles are becoming more prevalent than studies of other cellular structures. In this analytical review, mitochondria are conditionally placed in a certain cellular center, which is responsible for both energy production and other non-energetic functions, without which the existence of not only the eukaryotic cell itself, but also the entire organism is impossible. Taking into account the high multifunctionality of mitochondria, such a fundamentally new scheme of cell functioning organization, including mitochondrial management of processes that determine cell survival and death, may be justified. Considering that this issue is dedicated to the memory of V. P. Skulachev, who can be called mitocentric, due to the history of his scientific activity almost entirely aimed at studying mitochondria, this work examines those aspects of mitochondrial functioning that were directly or indirectly the focus of attention of this outstanding scientist. We list all possible known mitochondrial functions, including membrane potential generation, synthesis of Fe-S clusters, steroid hormones, heme, fatty acids, and CO₂. Special attention is paid to the participation of mitochondria in the formation and transport of water, as a powerful biochemical cellular and mitochondrial regulator. The history of research on reactive oxygen species that generate mitochondria is subject to significant analysis. In the section “Mitochondria in the center of death”, special emphasis is placed on the analysis of what role and how mitochondria can play and determine the program of death of an organism (phenoptosis) and the contribution made to these studies by V. P. Skulachev.

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KEY WORDS: mitochondria, cell, organism, phenoptosis, death, membrane potential, water, swelling, uncoupling, CO₂, steroids, heme, fatty acids, reactive oxygen species

DOI: 10.1134/S0006297924020044

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