Adsorption of Acylhydroperoxy-Derivatives of Phospholipids from Biomembranes by Blood Plasma Lipoproteins

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Vadim Z. Lankin^1,a*, Alla K. Tikhaze¹, Valeria Y. Kosach¹, and Galina G. Konovalova¹

¹National Medical Research Center of Cardiology named after Academician E. I. Chazov, Ministry of Health of the Russian Federation, 121552 Moscow, Russia

^* To whom correspondence should be addressed.

Received February 11, 2023; Revised February 21, 2023; Accepted March 21, 2023

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It has been established that acylhydroperoxy derivatives of phospholipids from oxidized rat liver mitochondria are captured predominantly by LDL particles but not by HDL during co-incubation with blood plasma lipoproteins, which refutes the previously suggested hypothesis about the involvement of HDL in the reverse transport of oxidized phospholipids and confirms the possibility of different mechanisms of lipohydroperoxide accumulation in LDL during oxidative stress.

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KEY WORDS: oxidized phospholipids, transmembrane transport of lipoperoxides, low-density lipoproteins (LDL), high-density lipoproteins (HDL)

DOI: 10.1134/S0006297923050127

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