REVIEW: Polymeric Drug Delivery Systems in Biomedicine

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Ivan A. Gulyaev^1,a*, Maria B. Sokol¹, Mariia R. Mollaeva¹, Maksim A. Klimenko¹, Nikita G. Yabbarov¹, Margarita V. Chirkina¹, Elena D. Nikolskaya^1,b*

¹Emanuel Institute of Biochemical Physics of Russian Academy of Sciences, 119334 Moscow, Russia

^* To whom correspondence should be addressed.

Received: September 24, 2024; Revised: October 8, 2024; Accepted: October 22, 2024

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Our review examines the key aspects of using polymeric carriers in biomedicine. The section “Polymers for Biomedicine” provides an overview of different types of polymers, their structural features and properties that determine their use as drug delivery vehicles. The section “Polymeric Carriers” characterizes the role of polymeric delivery systems in modern medicine. The main forms of polymeric carriers are described, as well as their key advantages for drug delivery. The section “Preclinical and Clinical Trials of Polymeric Drug Carriers” reviews the examples of clinical and preclinical studies of polymeric forms used for antitumor therapy, therapy for bacterial and infectious diseases. The final section “Targeted Drug Delivery Systems” is devoted to the discussion of approaches, as well as ligands that provide targeted drug delivery using polymeric carriers. We have paid special attention to modern approaches for increasing the efficacy of antibacterial therapy using vector molecules.

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KEY WORDS: polymeric nanoparticles, targeted drug delivery, antitumor therapy, antibacterial therapy, antiviral therapy

DOI: 10.1134/S0006297924603976

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