REVIEW: Free Radical Lipid Peroxidation Induced by Reactive Halogen Species

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Oleg M. Panasenko^1,a*, Yury A. Vladimirov¹, and Valery I. Sergienko¹

¹Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological Agency, Moscow, Russia

Received June 13, 2023; Revised July 8, 2023; Accepted July 15, 2023

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The review is devoted to the mechanisms of free radical lipid peroxidation (LPO) initiated by reactive halogen species (RHS) produced in mammals, including humans, by heme peroxidase enzymes, primarily myeloperoxidase (MPO). It has been shown that RHS can participate in LPO both in the initiation and branching steps of the LPO chain reactions. The initiation step of RHS-induced LPO mainly involves formation of free radicals in the reactions of RHS with nitrite and/or with amino groups of phosphatidylethanolamine or Lys. The branching step of the oxidative chain is the reaction of RHS with lipid hydroperoxides, in which peroxyl and alkoxyl radicals are formed. The role of RHS-induced LPO in the development of human inflammatory diseases (cardiovascular and neurodegenerative diseases, cancer, diabetes, rheumatoid arthritis) is discussed in detail.

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KEY WORDS: lipid peroxidation, reactive halogen species, hypochlorous acid, myeloperoxidase, free radicals, halogenative stress, human inflammatory diseases

DOI: 10.1134/S0006297924140098

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