REVIEW: Alcohol-Induced Activation of Chemokine System and Neuroinflammation Development

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Ekaterina V. Mikhalitskaya^1,a*, Natalya M. Vyalova¹, Nikolay A. Bokhan¹, Svetlana A. Ivanova¹

¹Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 634014 Tomsk, Russia

^* To whom correspondence should be addressed.

Received: May 15, 2024; Revised: September 27, 2024; Accepted: September 30, 2024

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Chemokines are immunoregulatory proteins with pleiotropic functions involved in neuromodulation, neurogenesis, and neurotransmission. The way chemokines affect the CNS plays an important role in modulating various conditions that could have negative impact on CNS functions, including development of alcohol use disorders. In this review, we analyzed the literature data available on the problem of chemokine participation in pathogenesis, clinical presentation, and remission of alcohol use disorders both in animal models and in the study of patients with alcoholism. The presented information confirms the hypothesis that the alcohol-induced chemokine production could modulate chronic neuroinflammation. Thus, the data summarized and shown in this review are focused on the relevant direction of research in the field of psychiatry, which is in demand by both scientists and clinical specialists.

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KEY WORDS: alcohol use disorders, addiction, chemokines, neuroinflammation

DOI: 10.1134/S0006297924110038

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