REVIEW: IGF Signaling in the Heart in Health and Disease

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Daria A. Adasheva¹, Daria V. Serebryanaya^1,2,a*

¹Department of Biochemistry, Faculty of Biology, Lomonosov Moscow State University, 119234 Moscow, Russia

²Pirogov Russian National Research Medical University, 117997 Moscow, Russia

^* To whom correspondence should be addressed.

Received: February 27, 2024; Revised: June 11, 2024; Accepted: June 22, 2024

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One of the most vital processes of the body is the cardiovascular system’s proper operation. Physiological processes in the heart are regulated by the balance of cardioprotective and pathological mechanisms. The insulin-like growth factor system (IGF system, IGF signaling pathway) plays a pivotal role in regulating growth and development of various cells and tissues. In myocardium, the IGF system provides cardioprotective effects as well as participates in pathological processes. This review summarizes recent data on the role of IGF signaling in cardioprotection and pathogenesis of various cardiovascular diseases, as well as analyzes severity of these effects in various scenarios.

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KEY WORDS: cardiovascular diseases, cardiomyocytes, insulin-like growth factors IGF-I and IGF-II, IGF-binding proteins (IGFBP), cardioprotective effect, IGFBP-4, PAPP-A

DOI: 10.1134/S0006297924080042

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