REVIEW: Genomic Imprinting and Random Monoallelic Expression

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Yaroslava V. Lobanova^1,2and Svetlana V. Zhenilo^1,a*

¹Federal Research Center of Biotechnology, Russian Academy of Sciences, 119071 Moscow, Russia

²Institute of Gene Biology, Russian Academy of Sciences, 119334 Moscow, Russia

Received October 21, 2023; Revised December 8, 2023; Accepted December 8, 2023

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The review discusses the mechanisms of monoallelic expression, such as genomic imprinting, in which gene transcription depends on the parental origin of the allele, and random monoallelic transcription. Data on the regulation of gene activity in the imprinted regions are summarized with a particular focus on the areas controlling imprinting and factors influencing the variability of the imprintome. The prospects of studies of the monoallelic expression are discussed.

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KEY WORDS: imprinting, random monoallelic expression, DNA methylation, ZNF57, epigenetics

DOI: 10.1134/S000629792401005X

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