REVIEW: Immune Privileges as a Result of Mutual Regulation of Immune and Stem Systems

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Dmitriy V. Karpenko^a

Laboratory of Epigenetic Regulation of Hematopoiesis, National Medical Research Center for Hematology, 125167 Moscow, Russia

Received June 19, 2023; Revised October 9, 2023; Accepted October 10, 2023

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Immune privileges of cancer stem cells is a well-known and widely studied problem, as presence of such cells in tumors is associated with refractoriness, recurrence, and metastasis. Accumulating evidence also suggests presence of immune privileges in non-pathological stem cells in addition to their other defense mechanisms against damaging factors. This similarity between pathological and normal stem cells raises the question of why stem cells have such a potentially dangerous property. Regulation of vital processes of autoimmunity control and regeneration realized through interactions between immune cells, stem cells, and their microenvironment are reviewed in this work as causes of formation of the stem cell immune privilege. Deep mutual integration between regulations of stem and immune cells is noted. Considering diversity and complexity of mutual regulation of stem cells, their microenvironment, and immune system, I suggest the term “stem system”.

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KEY WORDS: autoimmunity, regeneration, stem cell, cancer stem cell, stem system, immune privileges, nestin

DOI: 10.1134/S0006297923110123

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