REVIEW: Molecular Mechanisms of Astrocyte Involvement in Synaptogenesis and Brain Synaptic Plasticity

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Leonid G. Khaspekov^1,a* and Lidia E. Frumkina¹

¹Research Center of Neurology, 125367 Moscow, Russia

^* To whom correspondence should be addressed.

Received November 9, 2022; Revised March 2, 2023; Accepted March 3, 2023

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Astrocytes perform a wide range of important functions in the brain. As structural and functional components of synapses, astrocytes secrete various factors (proteins, lipids, small molecules, etc.) that bind to neuronal receptor and contribute to synaptogenesis and regulation of synaptic contacts. Astrocytic factors play a key role in the formation of neural networks undergoing short- and long-term synaptic morphological and functional rearrangements essential in the memory formation and behavior. The review summarizes the data on the molecular mechanisms mediating the involvement of astrocyte-secreted factors in synaptogenesis in the brain and provides up-to-date information on the role of astrocytes and astrocytic synaptogenic factors in the long-term plastic rearrangements of synaptic contacts.

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KEY WORDS: astrocytes, synaptogenesis, synaptic plasticity

DOI: 10.1134/S0006297923040065

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