REVIEW: Age-Related Changes in Extracellular Matrix

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Zulfiia G. Guvatova^1,2, Pavel V. Borisov¹, Alexey A. Alekseev², and Alexey A. Moskalev^1,2,a*

¹Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia

²Russian Clinical Research Center for Gerontology, Pirogov Russian National Research Medical University, Ministry of Healthcare of the Russian Federation, 129226 Moscow, Russia

^* To whom correspondence should be addressed.

Received August 29, 2022; Revised November 14, 2022; Accepted November 14, 2022

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Extracellular matrix (ECM) is an extracellular tissue structure that, in addition to mechanical support to the cell, is involved in regulation of many cellular processes, including chemical transport, growth, migration, differentiation, and cell senescence. Age-related changes in the structure and composition of the matrix and increase of ECM stiffness with age affect functioning of many tissues and contribute to the development of various pathological conditions. This review considers age-related changes of ECM in various tissues and organs, in particular, effect of ECM changes on aging is discussed.

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KEY WORDS: extracellular matrix, aging

DOI: 10.1134/S0006297922120112

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