REVIEW: Role of Tumor Suppressor PTEN and Its Regulation in Malignant Transformation of Endometrium

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Alina M. Perevalova^1,a*, Vyacheslav S. Kobelev², Virab G. Sisakyan³, Lyudmila F. Gulyaeva^1,2, and Vladimir O. Pustylnyak^1,2

¹Novosibirsk State University, 630090 Novosibirsk, Russia

²Federal Research Center of Fundamental and Translational Medicine, 630117 Novosibirsk, Russia

³Novosibirsk Regional Oncology Center, 630108 Novosibirsk, Russia

^* To whom correspondence should be addressed.

Received May 2, 2022; Revised August 24, 2022; Accepted September 19, 2022

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Tumor-suppressive effects of PTEN are well-known, but modern evidence suggest that they are not limited to its ability to inhibit pro-oncogenic PI3K/AKT signaling pathway. Features of PTEN structure facilitate its interaction with substrates of different nature and display its activity in various ways both in the cytoplasm and in cell nuclei, which makes it possible to take a broader look at its ability to suppress tumor growth. The possible mechanisms of the loss of PTEN effects are also diverse – PTEN can be regulated at many levels, leading to change in the protein activity or its amount in the cell, while their significance for the development of malignant tumors has yet to be studied. Here we summarize the current data on the PTEN structure, its functions and changes in its regulatory mechanisms during malignant transformation of the cells, focusing on one of the most sensitive to the loss of PTEN types of malignant tumors – endometrial cancer.

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KEY WORDS: PTEN, endometrial cancer, endometrial hyperplasia, gene regulation

DOI: 10.1134/S0006297922110104

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