REVIEW: Segregation of α- and β-Globin Gene Cluster in Vertebrate Evolution: Chance or Necessity?

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Olga V. Iarovaia^1,a*, Sergey V. Ulianov^1,2, Elena S. Ioudinkova¹, and Sergey V. Razin^1,2

¹Institute of Gene Biology, Russian Academy of Sciences, 119334 Moscow, Russia

²Faculty of Biology, Lomonosov Moscow State University, 119234 Moscow, Russia

^* To whom correspondence should be addressed.

Received July 22, 2022; Revised August 18, 2022; Accepted August 19, 2022

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The review is devoted to the patterns of evolution of α- and β-globin gene domains. A hypothesis is presented according to which segregation of the ancestral cluster of α/β-globin genes in Amniota occurred due to the performance by α-globins and β-globins of non-canonical functions not related to oxygen transport.

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KEY WORDS: evolution of α- and β-globin genes, regulation of transcription, non-canonical functions of α- and β-globins

DOI: 10.1134/S0006297922090140

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