REVIEW: Studying of Molecular Regulation of Developmental Processes of Lower Metazoans Exemplified by Cnidaria Using High-Throughput Sequencing

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Taisia V. Erofeeva^1,2, Anastasia P. Grigorenko^1,2,a*, Fedor E. Gusev^1,2, Igor A. Kosevich^1,3, and Evgeny I. Rogaev^1,2,3,4

¹Department Research Center for Genetics and Life Sciences, Sirius University of Science and Technology, 354349 Krasnodar Region, Sochi, Russia

²Vavilov Institute of General Genetics, Russian Academy of Sciences, 119991 Moscow, Russia

³Lomonosov Moscow State University, 119234 Moscow, Russia

⁴Department of Psychiatry, UMass Chan Medical School, Shrewsbury, MA 01545, USA

^* To whom correspondence should be addressed.

Received October 28, 2021; Revised December 13, 2021; Accepted January 17, 2022

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A unique set of features and characteristics of species of the Cnidaria phylum is the one reason that makes them a model for a various studies. The plasticity of a life cycle and the processes of cell differentiation and development of an integral multicellular organism associated with it are of a specific scientific interest. A new stage of development of molecular genetic methods, including methods for high-throughput genome, transcriptome, and epigenome sequencing, both at the level of the whole organism and at the level of individual cells, makes it possible to obtain a detailed picture of the development of these animals. This review examines some modern approaches and advances in the reconstruction of the processes of ontogenesis of cnidarians by studying the regulatory signal transduction pathways and their interactions.

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KEY WORDS: Cnidaria, development, sequencing technologies, genomics, signaling pathways

DOI: 10.1134/S0006297922030075

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