REVIEW: Modern Perspective on Metabolic Reprogramming in Malignant Neoplasms

---

D. A. Korshunov^1,a*, I. V. Kondakova¹, and E. E. Shashova¹

¹Tomsk National Research Medical Center, 634009 Tomsk, Russia

^* To whom correspondence should be addressed.

Received March 1, 2019; Revised May 6, 2019; Accepted June 20, 2019

---

Metabolic reprogramming is one of the central features of transformed cells. Elucidation of interactions between oncogenic signaling and cell metabolic processes has become the basis for extensive studies of metabolism reprogramming in tumor tissue. The review summarizes the key results of studies on the catabolic and anabolic rearrangements in tumor cells with special emphasis on carbohydrate, lipid, amino acid, and acetate metabolism determining the cancer phenotype of cells.

---

KEY WORDS: Warburg effect, pentose phosphate pathway, glutamine, lipogenesis, acetate

DOI: 10.1134/S000629791910002X

---