REVIEW: Structural Features of Actin Cytoskeleton Required for Endotheliocyte Barrier Function

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A. S. Shakhov¹, V. B. Dugina¹, and I. B. Alieva^1,a*

¹Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russia

^* To whom correspondence should be addressed.

Received October 5, 2018; Revised November 22, 2018; Accepted November 22, 2018

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Cytoplasmic actin structures are essential components of the eukaryotic cytoskeleton. According to the classic concepts, actin structures perform contractile and motor functions, ensuring the possibility of cell shape changes during cell spreading, polarization, and movement both in vitro and in vivo, from the early embryogenesis stages and throughout the life of a multicellular organism. Intracellular organization of actin structures, their biochemical composition, and dynamic properties play a key role in the realization of specific cellular and tissue functions and vary in different cell types. This paper is a review of recent studies on the organization and properties of actin structures in endotheliocytes, interaction of these structures with other cytoskeletal components and elements involved in cell adhesion, as well as their role in the functional activity of endothelial cells.

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KEY WORDS: endothelium, endotheliocyte, cytoskeleton, actin structures of the cytoskeleton, β-actin, γ-actin, endothelial microparticles

DOI: 10.1134/S0006297919040035

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