REVIEW: Anti-amyloid Therapy of Alzheimer’s Disease: Current State and Prospects

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S. A. Kozin¹, E. P. Barykin¹, V. A. Mitkevich^1,a*, and A. A. Makarov^1,b

¹Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia

^* To whom correspondence should be addressed.

Received May 17, 2018; Revision received June 4, 2018

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Drug development for the treatment of Alzheimer’s disease (AD) has been for a long time focused on agents that were expected to support endogenous β-amyloid (Aβ) in a monomeric state and destroy soluble Aβ oligomers and insoluble Aβ aggregates. However, this strategy has failed over the last 20 years and was eventually abandoned. In this review, we propose a new approach to the anti-amyloid AD therapy based on the latest achievements in understanding molecular causes of cerebral amyloidosis in AD animal models.

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KEY WORDS: Alzheimer’s disease, amyloid-β, isoaspartate, zinc, protein–protein complexes, cerebral β-amyloidosis

DOI: 10.1134/S0006297918090079

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