MINI-REVIEW: Inorganic Polyphosphate and Cancer

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E. V. Kulakovskaya¹, M. Yu. Zemskova^1,2, and T. V. Kulakovskaya^1,a*

¹Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences, 142290 Pushchino, Moscow Region, Russia

²Moscow State Regional University, Research and Education Center of Pushchino, 142290 Pushchino, Moscow Region, Russia

^* To whom correspondence should be addressed.

Received April 2, 2018; Revision received April 17, 2018

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This review presents data on the relationship between inorganic polyphosphate metabolism and carcinogenesis including participation of polyphosphates in the regulation of activity of mTOR and other proteins involved in carcinogenesis, the role of h-prune protein (human polyphosphatase) in cell migration and metastasis formation, the prospects for using polyphosphates and inhibitors of polyphosphate metabolism enzymes as agents for controlling cell proliferation and migration.

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KEY WORDS: inorganic polyphosphates, cancer, metastasis, cell motility, h-prune protein, mTOR

DOI: 10.1134/S0006297918080072

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