REVIEW: Mobility of Nuclear Components and Genome Functioning

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E. A. Arifulin^1,a*, Y. R. Musinova^1,2,3, Y. S. Vassetzky^1,2,3,4, and E. V. Sheval^1,2

¹Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia

²LIA 1066 LFR2O French-Russian Joint Cancer Research Laboratory, 94805 Villejuif, France

³Koltzov Institute of Developmental Biology, Russian Academy of Sciences, 119334 Moscow, Russia

⁴UMR8126, CNRS, Université Paris-Sud, Institut de Cancérologie Gustave Roussy, 94805 Villejuif, France

^* To whom correspondence should be addressed.

Received November 15, 2017; Revision received December 27, 2017

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Cell nucleus is characterized by strong compartmentalization of structural components in its three-dimensional space. Certain genomic functions are accompanied by changes in the localization of chromatin loci and nuclear bodies. Here we review recent data on the mobility of nuclear components and the role of this mobility in genome functioning.

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KEY WORDS: nucleus, genome, chromatin, nuclear bodies, mobility

DOI: 10.1134/S0006297918060068

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