REVIEW: Bacterial Therapy and Mitochondrial Therapy

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V. A. Popkov^1,2, E. Y. Plotnikov^2*, D. N. Silachev², L. D. Zorova², I. B. Pevzner², S. S. Jankauskas², S. D. Zorov¹, N. V. Andrianova¹, V. A. Babenko¹, and D. B. Zorov^2*

¹Lomonosov Moscow State University, Faculty of Bioengineering and Bioinformatics, 119991 Moscow, Russia

²Lomonosov Moscow State University, Belozersky Institute of Physico-Chemical Biology, 119991 Moscow, Russia; E-mail: plotnikov@genebee.msu.ru, zorov@genebee.msu.ru

^* To whom correspondence should be addressed.

Received September 11, 2017; Revision received September 20, 2017

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Current methods for treatment of cellular and organ pathologies are extremely diverse and constantly evolving, going beyond the use of drugs, based on chemical interaction with biological targets to normalize the functions of the system. Because pharmacological approaches are often untenable, recent strategies in the therapy of different pathological conditions are of particular interest through introducing into the organism of some living system or its components, in particular, bacteria or isolated subcellular structures such as mitochondria. This review describes the most interesting and original examples of therapy using bacteria and mitochondria, which in perspective can dramatically change our views on the principles for the treatment of many diseases. Thus, we analyze such therapeutic effects from the perspective of the similarities between mitochondria and bacteria as the evolutionary ancestors of mitochondria.

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KEY WORDS: bacteria, mitochondria, microbiota, pathology, transplantation, treatment

DOI: 10.1134/S0006297917120148

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