MINI-REVIEW: PDX1: A Unique Pancreatic Master Regulator Constantly Changes Its Functions during Embryonic Development and Progression of Pancreatic Cancer

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T. V. Vinogradova^* and E. D. Sverdlov

Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia; E-mail: vintv56@gmail.com

^* To whom correspondence should be addressed.

Received April 28, 2017; Revision received May 22, 2017

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Multifunctional activity of the PDX1 gene product is reviewed. The PDX1 protein is unique in that being expressed exclusively in the pancreas it exhibits various functional activities in this organ both during embryonic development and during induction and progression of pancreatic cancer. Hence, PDX1 belongs to the family of master regulators with multiple and often antagonistic functions.

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KEY WORDS: dedifferentiation, transdifferentiation, transcription factors, suppressor, acinar cell, duct cell

DOI: 10.1134/S000629791708003X

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