REVIEW: Molecular Mechanisms Mediating Involvement of Glial Cells in Brain Plastic Remodeling in Epilepsy

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L. G. Khaspekov^* and L. E. Frumkina

Research Center of Neurology, Department of Brain Research, 105064 Moscow, Russia; E-mail: khaspekleon@mail.ru

^* To whom correspondence should be addressed.

Received October 29, 2016; Revision received November 28, 2016

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In this review we summarize published data on the involvement of glial cells in molecular mechanisms underlying brain plastic reorganization in epilepsy. The role of astrocytes as glial elements in pathological plasticity in epilepsy is discussed. Data on the involvement of aquaporin-4 in epileptogenic plastic changes and on participation of microglia and extracellular matrix in dysregulation of synaptic transmission and plastic remodeling in epileptic brain tissue are reviewed.

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KEY WORDS: glial cells, neurons, epilepsy, plasticity

DOI: 10.1134/S0006297917030178

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