REVIEW: Inflammatory Immune Infiltration in Human Tumors: Role in Pathogenesis and Prognostic and Diagnostic Value

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A. V. Bogolyubova^1,2* and P. V. Belousov^1,2

¹Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia; E-mail: apollinariya.bogolyubova@gmail.com

²Lomonosov Moscow State University, Biological Faculty, 119991 Moscow, Russia

^* To whom correspondence should be addressed.

Received June 23, 2016; Revision received July 13, 2016

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The cellular microenvironment directly and indirectly influences tumor development and possesses prognostic and in some cases diagnostic value. Over the years, understanding of structural organization of the immune/inflammatory moiety of neoplasms as well as in-depth phenotypic and transcriptomic profiling of its cellular components together provide more and more insights in both basic and translational medical science. In this review, we will discuss the specific roles of various stromal cells and their impact on neoplastic progression as well as address the use of quantitative and phenotypic analysis of immune/inflammatory infiltrate for diagnostics and predicting the clinical course of human malignancies.

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KEY WORDS: cellular microenvironment of tumors, immune infiltration, melanoma, breast cancer, thyroid cancer, colorectal cancer

DOI: 10.1134/S0006297916110043

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