Therapeutic Doses of SkQ1 Do Not Induce Cytochromes P450 in Rat Liver

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K. N. Myasoedova^1,2* and D. N. Silachev^2,3

¹Lomonosov Moscow State University, Faculty of Fundamental Medicine, 119991 Moscow, Russia; fax: (499) 726-5547; E-mail: skulach@belozersky.msu.ru; kseniamyasoedova@gmail.com

²Lomonosov Moscow State University, Institute of Mitoengineering, 119991 Moscow, Russia; E-mail: proteins@mail.ru

³Lomonosov Moscow State University, Belozersky Institute of Physico-Chemical Biology, 119991 Moscow, Russia

^* To whom correspondence should be addressed.

Received June 20, 2014

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The effect of SkQ1 (a mitochondria-targeted antioxidant) on the level of cytochromes P450 in rat liver was studied. It was found that administration of therapeutic dose of SkQ1 with drinking water for 5 days (250 nmol/kg of body weight per day) did not alter the level of cytochromes P450. Under the same conditions, the standard dose of phenobarbital used for the induction of cytochromes P450 caused the 2.7-fold increase in the content of these cytochromes. We conclude that therapeutic doses of SkQ1 do not induce cytochromes P450 in rats.

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KEY WORDS: cytochrome P450, mitochondria-targeted antioxidant, SkQ1

DOI: 10.1134/S0006297914100149

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