REVIEW: Mitochondrial Production of Reactive Oxygen Species

---

V. G. Grivennikova^* and A. D. Vinogradov

Department of Biochemistry, Biological Faculty, Lomonosov Moscow State University, 119991 Moscow, Russia; E-mail: vgrivennikova@mail.ru; adv@biochem.bio.msu.su

^* To whom correspondence should be addressed.

Received June 18, 2013

---

Numerous biochemical studies are aimed at elucidating the sources and mechanisms of formation of reactive oxygen species (ROS) because they are involved in cellular, organ-, and tissue-specific physiology. Mitochondria along with other cellular organelles of eukaryotes contribute significantly to ROS formation and utilization. This review is a critical account of the mitochondrial ROS production and methods for their registration. The physiological and pathophysiological significance of the mitochondrially produced ROS are discussed.

---

KEY WORDS: oxidoreductases, respiratory chain, ROS production, mitochondria

DOI: 10.1134/S0006297913130087

---