REVIEW: New Functions of Small Nucleolar RNAs

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J. A. Makarova^1,2*, S. M. Ivanova³, A. G. Tonevitsky^2,4,5, and A. I. Grigoriev⁶

¹Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, ul. Vavilova 32, 119991 Moscow, Russia; fax: (499) 135-1405; E-mail: j-makarova@yandex.ru

²Science and Technology Center Bioclinicum, ul. Ugreshskaya 2/85, 115088 Moscow, Russia; E-mail: mail@bioclinicum.com

³Semashko Hospital at Lublino, ul. Stavropolskaya 23/1, 109386 Moscow, Russia; E-mail: ivanova.revm@yandex.ru

⁴Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, ul. Baltiiskaya 8, 125315 Moscow, Russia

⁵Lomonosov Moscow State University, 119991 Moscow, Russia; E-mail: tonevitsky@mail.ru

⁶State Research Center of the Russian Federation, Institute of Biomedical Problems, Russian Academy of Sciences, Khoroshevskoe Shosse 76A, 123007 Moscow, Russia; E-mail: grigoriev@imbp.ru

^* To whom correspondence should be addressed.

Received January 30, 2013; Revision received February 21, 2013

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Small nucleolar RNAs (snoRNAs) are one of the most abundant and well-studied groups of non-coding RNAs. snoRNAs are mostly engaged in processing of rRNA. However, recent data indicate that snoRNAs are also involved in other processes including regulation of alternative splicing, translation and oxidative stress. snoRNAs are also involved in pathogenesis of some hereditary diseases and cancer. Therefore, the range of snoRNAs’ functions is significantly wider than it has been assumed earlier.

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KEY WORDS: snoRNA, scaRNA, sdRNA, miRNA, noncoding RNA, RNA silencing, oncogenesis

DOI: 10.1134/S0006297913060096

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