On the Problem of Identification of Intracellular Signaling Pathways

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V. Yu. Denisenko and T. I. Kuzmina^*

All-Russian Research Institute of Farm Animal Genetics and Breeding, Russian Academy of Agricultural Sciences, Moskovskoe Shosse 55a, 196600 Pushkin, St. Petersburg, Russia; fax: (812) 465-9989; E-mail: prof.kouzmina@mail.ru

^* To whom correspondence should be addressed.

Received November 21, 2012

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A hypothesis is proposed about the involvement of mitochondria in transduction of intracellular signals. In addition to the endoplasmic reticulum responsible for fluctuations of intracellular concentration of Ca²⁺, mitochondria are supposed to determine changes in the concentration of the secondary messenger cAMP. This hypothesis extends our ideas concerning mechanisms of intracellular signal transduction.

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KEY WORDS: endoplasmic reticulum, calcium, mitochondria, cAMP

DOI: 10.1134/S0006297913040135

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