REVIEW: Natural Antibodies to Nucleic Acids

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V. N. Buneva^1,2, M. A. Krasnorutskii¹, and G. A. Nevinsky^1,2*

¹Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences, pr. Lavrentieva 8, 630090 Novosibirsk, Russia; fax: (383) 333-3677; E-mail: nevinsky@niboch.nsc.ru

²Novosibirsk State University, ul. Pirogova 2, 630090 Novosibirsk, Russia; fax: (383) 330-3255; E-mail: buneva@niboch.nsu.ru

^* To whom correspondence should be addressed.

Received April 24, 2012; Revision received September 24, 2012

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Blood of healthy donors contains low concentrations of autoantibodies to its own components, including DNA and RNA. Increased concentrations of antibodies to DNA and RNA have been found in blood of people and animals with autoimmune diseases and viral and bacterial infections. Detection of different antibodies with catalytic activities, including abzymes with DNase and RNase activities, is the earliest indicator of the development of some autoimmune diseases. This review reveals possible mechanisms of generation of anti-DNA and anti-RNA antibodies without catalytic activities and abzymes in normal organisms and in organisms with different pathologies. A possible role of these autoantibodies and the reasons of their exceptional diversity in normal organisms and in organisms with different autoimmune diseases are discussed.

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KEY WORDS: antibodies against DNA and RNA, natural abzymes, healthy donors, autoimmune diseases

DOI: 10.1134/S0006297913020028

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