Cellularity Loss and Dilman’s Problem: An in silico Study

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V. A. Chistyakov^1,2* and Y. V. Denisenko¹

¹Research Institute of Biology, Southern Federal University, pr. Stachki 194/1, 344090 Rostov-on-Don, Russia; E-mail: vladimirchi@yandex.ru

²Rostov State Medical University, Pereulok Nakhichevansky 29, 344022 Rostov-on-Don, Russia; fax: (863) 201-4390

^* To whom correspondence should be addressed.

Received April 1, 2012

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We assume that prolonged trends of increasing concentration of hormones could be a consequence of deterioration of functioning of glands producing inhibitors of their synthesis. Such deterioration would result from loss of cellularity of the glands. Experiments in silico carried out using the model at http://www.winmobile.biz/monstr/ show that, in principle, the diversity of hormonal effects that accompany phenoptosis of multicellular organisms can be provided with a simple “software mechanism”. This mechanism is based on the gradual loss of cellularity as a result of continuous run of apoptosis in some cells of the glands due to natural fluctuations in levels of intracellular inducers of apoptosis. The main practical sense of our work lies in the illustration of the fact that substances inhibiting cellularity loss can theoretically be effective suppressors of hormonal changes characteristic for aging.

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KEY WORDS: phenoptosis, apoptosis, aging, imitation modeling, cellularity loss, hormones, elevation theory

DOI: 10.1134/S0006297912070115

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