REVIEW: Oxidative Stress in Yeast

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V. I. Lushchak

Department of Biochemistry, Vassyl Stefanyk Precarpathian National University, 57 Shevchenko Str., Ivano-Frankivsk, 76025, Ukraine; fax: +38 (0342) 714-683; E-mail: lushchak@pu.if.ua

Received December 15, 2008; Revision received October 5, 2009

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The mechanisms of production and elimination of reactive oxygen species in the cells of the budding yeast Saccharomyces cerevisiae are analyzed. Coordinative role of special regulatory proteins including Yap1p, Msn2/4p, and Skn7p (Pos9p) in regulation of defense mechanisms in S. cerevisiae is described. A special section is devoted to two other well-studied species from the point of view of oxidative stress – Schizosaccharomyces pombe and Candida albicans. Some examples demonstrating the use of yeast for investigation of apoptosis, aging, and some human diseases are given in the conclusion part.

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KEY WORDS: yeast, Saccharomyces cerevisiae, Schizosaccharomyces pombe, Candida albicans, oxidative stress response, regulatory proteins

DOI: 10.1134/S0006297910030041

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