REVIEW: Role of Acidosis, NMDA Receptors, and Acid-Sensitive Ion Channel 1a (ASIC1a) in Neuronal Death Induced by Ischemia

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N. K. Isaev^1,2*, E. V. Stelmashook², E. Y. Plotnikov¹, T. G. Khryapenkova¹, E. R. Lozier³, Y. V. Doludin³, D. N. Silachev¹, and D. B. Zorov¹

¹Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia; fax: (495) 939-3181; E-mail: isaev@genebee.msu.su

²Brain Research Department, Scientific Center of Neurology, Russian Academy of Medical Sciences, Pereulok Obukha 5, 105064 Moscow, Russia

³Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, 119992 Moscow, Russia

^* To whom correspondence should be addressed.

Received January 31, 2008; Revision received February 13, 2008

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This review collects data on the influence of intracellular and extracellular acidosis on neuronal viability and the effect of acidosis on neuronal damage progressing under brain ischemia/hypoxia. Particular attention is devoted to the involvement of ionotropic glutamic receptors and acid-sensitive ion channel 1a in these processes.

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KEY WORDS: acidosis, neurons, ischemia/hypoxia, pH, ASIC1a

DOI: 10.1134/S0006297908110011

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