REVIEW: Lysophospholipid Receptors in Cell Signaling

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T. I. Torkhovskaya^1,2*, O. M. Ipatova², T. S. Zakharova^1,2, M. M. Kochetova¹, and E. M. Khalilov¹

¹Institute of Physico-Chemical Medicine, ul. Malaya Pirogovskaya 1a, 119121 Moscow, Russia; fax: (495) 246-4884; E-mail: torti@mail.ru

²Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, ul. Pogodinskaya 10, 119121 Moscow, Russia

^* To whom correspondence should be addressed.

Received May 23, 2006; Revision received November 7, 2006

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There is increasing evidence that different phospholipids are involved in regulation of various cell processes and cell-cell interactions. Lysophospholipids (lysophosphatidic acid, lysophosphatidylcholine) and a number of lysosphingolipids play particular roles in these regulations. Their effects are mediated by specific G-protein-coupled receptors. G-Protein coupled signal transduction to the cell nucleus involving a chain of intracellular protein kinases induces the main effects in cells--growth, proliferation, survival, or apoptosis. This review summarizes recent data on various groups of lysophospholipid receptors and their cell signal transduction pathways.

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KEY WORDS: lysophospholipids, lysophosphatidic acid, G-protein, EDG receptors, sphingosine-1-phosphate

DOI: 10.1134/S0006297907020010

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