REVIEW: Active Defense under Oxidative Stress. The Antioxidant Responsive Element

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V. V. Lyakhovich¹, V. A. Vavilin¹, N. K. Zenkov², and E. B. Menshchikova^2*

¹Institute of Molecular Biology and Biophysics, Siberian Branch of the Russian Academy of Medical Sciences, ul. Timakova 2, 630117 Novosibirsk, Russia; fax: (383) 332-3147; E-mail: drugsmet@soramn.ru

²Scientific Center of Clinical and Experimental Medicine, Siberian Branch of the Russian Academy of Medical Sciences, ul. Timakova 2, 630117 Novosibirsk, Russia; fax: (383) 333-6456; E-mail: lemen@soramn.ru

^* To whom correspondence should be addressed.

Received March 13, 2006; Revision received April 11, 2006

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This review considers the mechanisms and factors that stimulate transcription of genes regulated by the antioxidant responsive element (ARE). The latter is important for cell defense under conditions of oxidative stress and also for detoxification of electrophilic xenobiotics. There are differences in regulation of intracellular homeostasis involving Nrf2-mediated activation of ARE and other redox-sensitive factors (NF-kappaB and AP-1).

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KEY WORDS: oxidative stress, antioxidant responsive element

DOI: 10.1134/S0006297906090033

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