REVIEW: The Role of Cytoskeleton in Glucose Regulation

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Zhuo Liu, Yong-Wei Zhang, Yong-Sheng Chang^*, and Fu-De Fang^*

National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China; fax: +86-106-525-3005; E-mail: fangfd@public3.bta.net.cn; changy@njc.org

^* To whom correspondence should be addressed.

Received June 3, 2005; Revision received November 30, 2005

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Cytoskeleton plays an important role in glucose regulation, mainly in the following three aspects. First, cytoskeleton regulates insulin secretion by guiding intracellular transport of insulin-containing vesicles and regulating release of insulin. Second, cytoskeleton is involved in insulin action by regulating distribution of insulin receptor substrate, GLUT4 translocation, and internalization of insulin receptor. In addition, cytoskeleton directs the intracellular distribution of glucose metabolism related enzymes including glycogen synthase and many glycolysis enzymes.

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KEY WORDS: cytoskeleton, glucose regulation, insulin

DOI: 10.1134/S0006297906050026

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