REVIEW: Sphingolipids in Tumor Metastases and Angiogenesis

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E. V. Dyatlovitskaya^* and A. G. Kandyba

Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, 117997 Moscow, Russia; E-mail: dyatl@ibch.ru

^* To whom correspondence should be addressed.

Received July 12, 2005; Revision received October 12, 2005

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This review article summarizes data on the involvement of sphingolipids (sphingosine-1-phosphate, sphingosine-1-phosphocholine, neutral glycosphingolipids, and gangliosides) in tumor metastases and angiogenesis.

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KEY WORDS: alpha-galactosylceramide, gangliosides, glycosphingolipids, sphingosine-1-phosphate, angiogenesis, metastasis

DOI: 10.1134/S0006297906040018

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