REVIEW: Non-apoptotic Functions of Caspase-3 in Nervous Tissue

N. V. Gulyaeva

Department of Functional Biochemistry of the Nervous System, Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, ul. Butlerova 5a, Moscow 117865, Russia; fax: (7-095) 952-4007; E-mail: nata_gul@pisem.net

Received May 6, 2003

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Some enzymes that have been recognized as “apoptotic” so far may be involved in important cellular processes not necessarily related to cell death in nervous tissue. The activity of caspase-3, an “apoptotic” enzyme, can be measured in normally functioning neurons. The results reported by several groups point to the possibility that caspases may be involved in nervous tissue function as top enzymes in the regulatory proteolytic cascade. A concept on a new mechanism of synaptic plasticity modulation involving caspase-3 has been formulated postulating a specific role of caspase-3 in normal brain functioning. The idea of synaptic plasticity modulation by caspase-3 is in line with data reported recently. For example, caspase-3 is possibly involved in the long-term potentiation (LTP) phenomenon since proteins that are key players of molecular mechanisms of LTP induction and maintenance are caspase-3 substrates. Experimental results on blocking LTP by a caspase-3 inhibitor confirm this concept.

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KEY WORDS: caspase, caspase-3, calpain, structural (cytoskeletal) proteins, signal transduction, neuroplasticity, apoptosis, long-term potentiation

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