Use of Serially Coupled Capillary Columns with Different Polarity of Stationary Phases for the Separation of the Natural Complex Volatile Mixture of the Marine Red Alga Corallina elongata

V. M. Dembitsky^* and M. Srebnik

Department of Medicinal Chemistry and Natural Products, School of Pharmacy, P.O. Box 12065, The Hebrew University of Jerusalem, Jerusalem 91120, Israel; fax: 9722-675-8201; E-mail: dvalery@cc.huji.ac.il

^* To whom correspondence should be addressed.

Received October 8, 2001; Revision received January 21, 2002

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Separation of a complex of natural volatile compounds using serially coupled capillary columns with different polarity of stationary phases by gas chromatography-mass spectrometry from the medicinal marine red alga Corallina elongata is reported. Nearly 200 hydrocarbons, halogen compounds, fatty acids, and other metabolites were found. Using this gas chromatography procedure we demonstrate the successful separation of different volatile organic compounds.

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KEY WORDS: biochemical method, red alga, Corallina elongata, GC-MS, serially coupled capillary columns

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