Synthesis of New Sulfonamide Inhibitors of Carbonic Anhydrase

O. Arslan^*, Ü. Çakýr, and H. Ý. Uðraþ

Balikesir University Faculty of Science and Art, Department of Chemistry, 10100 Balikesir, Turkey; E-mail: oktay@balikesir.edu.tr

^* To whom correspondence should be addressed.

Received January 28, 2002; Revision received February 12, 2002

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Four different derivatives of aromatic sulfonamides have been synthesized: 1,2-bis[(4-sulfonamidobenzamide)ethoxy]ethane (SBAM), 1,2-bis[(4-sulfonamidobenzoate)ethoxy]ethane, 1,2-bis[(2,4-dichloro-5-sulfonamidobenzamide)ethoxy]ethane, and 1,2-bis[(2,4-dichloro-5-sulfonamidobenzoate)ethoxy]ethane. SBAM is a most potent inhibitor on ciliary epithelium carbonic anhydrase and is approximately 13 times more active against carbonic anhydrase isoform II than against isoform I.

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KEY WORDS: inhibition, carbonic anhydrase, glaucoma, sulfonamides

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