Inhibition of Bovine Carbonic Anhydrase by New Sulfonamide Compounds

O. Arslan

Balikesir University Faculty of Science and Arts, Department of Chemistry, 10100 Balikesir, Turkey; E-mail: oktay@jupiter.balikesir.edu.tr

Received January 4, 2001; Revision received April 24, 2001

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Inhibitory effects of three new derivatives of 2-acetylamino-1,3,4-thiadiazole-5-sulfonamide on bovine carbonic anhydrase have been investigated. The new compounds are 2-(3-chloropropionylamino)-1,3,4-thiadiazole-5-sulfonamide, 2-(2,2-dichloroacetylamino)-1,3,4-thiadiazole-5-sulfonamide, and 2-(3-phenylpropionylamino)-1,3,4-thiadiazole-5-sulfonamide. The new compounds inhibit the esterase activity of carbonic anhydrase noncompetitively and have inhibition constants and I₅₀ values very similar to those for 2-acetylamino-1,3,4-thiadiazole-5-sulfonamide, the latter being clinically used in the treatment of glaucoma.

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KEY WORDS: inhibition, bovine carbonic anhydrase, sulfonamides

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