Sphinganine in Sphingomyelins of Tumors and Mouse Regenerating Liver

E. V. Dyatlovitskaya^1*, A. G. Kandyba¹, A. M. Kozlov², and O. G. Somova¹

¹Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117871 Russia; E-mail: dyatl@ibch.ru

²Institute of Experimental Diagnostics and Therapy of Tumors, Blokhin Oncology Research Center, Russian Academy of Medical Sciences, Kashirskoe Shosse 24, Moscow, 115478 Russia

^* To whom correspondence should be addressed.

Received April 20, 2000; Revision received June 9, 2000

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Contents of sphingenine (sphingosine) and sphinganine were studied in sphingomyelins of transplantable mouse tumors (hepatoma-22, melanoma B16, Lewis lung carcinoma, intestine carcinoma) and rat nephroma RA. The content of sphinganine was increased in sphingomyelins of hepatoma-22 and nephroma RA compared to sphingomyelins of liver and kidneys. Significant contents of sphinganine were also found in sphingomyelins of other studied tumors. The content of sphinganine in regenerating mouse liver (30 h after hepatectomy) was normal. The data suggest that disorders should exist in biosynthesis of sphingoid bases in tumors but not in normal rapidly proliferating tissue.

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KEY WORDS: sphinganine, sphingosine, sphingomyelin, tumor, regenerating liver

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