REVIEW: Catalytic Antibodies (Abzymes) Induced by Stable Transition-State Analogs

G. A. Nevinsky^*, D. V. Semenov, and V. N. Buneva

Novosibirsk Institute of Bioorganic Chemistry, Siberian Division of the Russian Academy of Sciences, ul. Lavrentieva 8, Novosibirsk, 630090 Russia; E-mail: Nevinsky@niboch.nsc.ru

^* To whom correspondence should be addressed.

Received April 10, 2000; Revision received June 5, 2000

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This review deals with recent advances in the generation of catalytic antibodies by the immunization of animals with stable transition-state analogs. Characteristic features in the functioning of such abzymes are considered in comparison with traditional enzymes.

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KEY WORDS: catalytic antibodies, stable transition-state analogs

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