REVIEW: Discrimination between Apoptosis and Necrosis of Neurons under Oxidative Stress

A. A. Boldyrev

International Biotechnological Center and Center of Molecular Medicine, Lomonosov Moscow State University, Moscow, 119899 Russia; fax: (7-095) 939-1398; E-mail: aab@genebee.msu.su

Received March 30, 2000

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Flow cytometric studies of rat cerebellum neurons are described under conditions inducing cell death. Using a double labeling technique, discrimination between apoptotic and necrotic cell transformations is demonstrated. Histidine containing neuropeptides were found to regulate cell stability, taking part in selection of the preferable way of neuronal death under oxidative stress.

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KEY WORDS: neurons, ischemia, reactive oxygen species, glutamate, apoptosis, necrosis, flow cytometry, histidine containing neuropeptides, carnosine, homocarnosine

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