Metabolic Features of the Adaptive Effect of Delta-Sleep Inducing Peptide and Piracetam under Hyperoxic Conditions

A. V. Lysenko^*, D. V. Alperovich, N. I. Uskova, and A. M. Mendzheritsky

Neurocybernetics Institute, Rostov State University, pr. Stachki 194/1, Rostov-on-Don, 344090 Russia; fax: (863-2) 28-0758; E-mail: mam@krink.rnd.runnet.ru

^* To whom correspondence should be addressed.

Received July 15, 1998; Revision received November 20, 1998

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Adaptive effects of delta-sleep inducing peptide (DSIP, 12 µg/100 g body weight, single intraperitoneal injection) and piracetam (3 mg/100 g body weight, daily intraperitoneal injection for 3 days) are manifested via differential changes in neurotransmitter amino acids (GABA, glutamate, aspartate), modulation of transport ATPase activity, and decreased accumulation of lipid peroxidation products (conjugated dienes, malonic dialdehyde, Schiff bases) in various fractions of neuronal membranes (myelin, synaptic and mitochondrial membranes) in the sensomotor cortex of rat brain. Under hyperbaric oxygenation (0.3 MPa for 2 h), the combination of DSIP and piracetam enhanced the protective effect of each compound.

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KEY WORDS: neuronal plasticity, adaptation, peptides, nootropic drugs, neurotransmitters

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