Lipid Peroxidation in Experimental Ischemia of the Brain

T. N. Fedorova^*, A. A. Boldyrev, and I. V. Gannushkina

Institute of Neurology, Russian Academy of Medical Sciences, Volokolamskoe Shosse 80, Moscow, 123367 Russia; fax: (095) 490-2408; E-mail: aab@bio.inevro.msk.ru

^* To whom correspondence should be addressed.

Received March 4, 1998; Revision received October 14, 1998

---

Lipid peroxidation was studied in the brain of Mongolian gerbils under conditions of complete ischemia followed by recirculation in the left hemisphere without recirculation in the right hemisphere. Thiobarbituric acid reactive products and the intensity of Fe²⁺-induced chemiluminescence were determined. The content of lipid peroxidation products in the brain tissue was increased not only under conditions of recirculation, but also at the ischemia stage during the limited access of oxygen. Thus, the destructive effect of free radicals may occur even during the early stage of ischemic injury of the brain.

---

KEY WORDS: brain, ischemia, recirculation, lipid peroxidation, antioxidants

---