Proteoglycan Composition in Cell Nuclei of Mouse Hepatoma

V. I. Rykova^* and E. V. Grigorieva

Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, pr. Lavrent'eva 10, Novosibirsk, 630090 Russia; fax: (3832) 356-558

^* To whom correspondence should be addressed.

Received January 13, 1998; Revision received June 10, 1998

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Cell nuclei of mouse hepatoma contain various proteoglycans (PG) which include heparan sulfate proteoglycan (HS-PG), dermatan sulfate proteoglycan (DS-PG), and chondroitin sulfate proteoglycan (CS AC-PG). The latter is not found in cell nuclei of normal mouse liver. Heparan sulfate (HS) and dermatan sulfate (DS) are the main constituents of carbohydrate chains of nuclear proteoglycans of tumor and normal cells, respectively. Changes in the composition of nuclear PG during malignant transformation are discussed considering the concept of their possible involvement in the regulation of cell mitotic activity.

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KEY WORDS: nucleus, proteoglycans, hepatoma, heparan sulfate, chondroitin sulfate, dermatan sulfate

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