Organization of Biochemical Systems: a Review

B. F. Poglazov¹

¹Bakh Institute of Biochemistry, Russian Academy of Sciences, Leninskii pr. 33, Moscow, 117071 Russia; fax: (7-095) 954-27-32.

Submitted June 17, 1996.

Our own data and data from the literature on molecular organization of biological systems from a single enzymatic complex to a large metabolon-like association are reviewed with emphasis on characterization of forces involved in the process of aggregation of protein molecules and the role of chaperons in organization of some complexes. A possible mechanism of chaperon transport along cytoskeleton structures is suggested. Problems in the theory of metabolon organization of enzymes and the role of an anchor in coordination of the action of multienzyme complexes are discussed.

KEY WORDS: multienzyme complex, supramolecular organization, ordered organization of enzymatic systems, chaperon, metabolon.

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